发明授权
US09228186B2 Methods and compositions for selecting siRNA of improved functionality
有权
用于选择改进功能的siRNA的方法和组合物
- 专利标题： Methods and compositions for selecting siRNA of improved functionality
- 专利标题（中）： 用于选择改进功能的siRNA的方法和组合物
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申请号： US14097551申请日： 2013-12-05
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公开(公告)号： US09228186B2公开(公告)日： 2016-01-05
- 发明人: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- 申请人： Thermo Fisher Scientific Inc.
- 申请人地址： US MA Waltham
- 专利权人： Thermo Fisher Scientific Inc.
- 当前专利权人： Thermo Fisher Scientific Inc.
- 当前专利权人地址： US MA Waltham
- 代理机构： Fenwick & West LLP
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C12N15/113 ; A61K31/713 ; C12N15/10 ; C12N15/11
摘要：
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
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