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公开(公告)号：US20220315922A1
公开(公告)日：2022-10-06
申请号：US17520530
申请日：2021-11-05
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , A61K31/713 , C12N15/10 , C12N15/11 , A61K48/00
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
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公开(公告)号：US20190233829A1
公开(公告)日：2019-08-01
申请号：US16378629
申请日：2019-04-09
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/122 , C12N2310/141
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for COX-2.
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公开(公告)号：US09719094B2
公开(公告)日：2017-08-01
申请号：US15255973
申请日：2016-09-02
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , A61K31/713
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/14
摘要： Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for SEC61G.
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4.发明申请公开(公告)号：US20160201058A1
公开(公告)日：2016-07-14
申请号：US14965816
申请日：2015-12-10
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对TTR的核苷酸序列的那些。
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5.发明授权公开(公告)号：US09228186B2
公开(公告)日：2016-01-05
申请号：US14097551
申请日：2013-12-05
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02 , C12N15/113 , A61K31/713 , C12N15/10 , C12N15/11
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对TTR的核苷酸序列的那些。
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公开(公告)号：US20180320182A1
公开(公告)日：2018-11-08
申请号：US16038029
申请日：2018-07-17
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , C12N15/10 , A61K31/713 , C12N15/11
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
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公开(公告)号：US20180201934A1
公开(公告)日：2018-07-19
申请号：US15862479
申请日：2018-01-04
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , A61K31/713 , C12N15/10 , C12N15/11 , C12N15/82
CPC分类号： C12N15/1137 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/31 , C12N2310/322 , C12N2320/10 , C12N2320/11 , C12N2320/13 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
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公开(公告)号：US10011836B2
公开(公告)日：2018-07-03
申请号：US14936403
申请日：2015-11-09
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/11 , C12N15/113 , A61K31/713 , C12N15/10 , C12N15/82
CPC分类号： C12N15/1138 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/8218 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2320/13 , C12N2330/31 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for F12.
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公开(公告)号：US09719092B2
公开(公告)日：2017-08-01
申请号：US15255829
申请日：2016-09-02
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/11 , C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/14
摘要： Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for CNTD2.
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公开(公告)号：US08937172B2
公开(公告)日：2015-01-20
申请号：US13764825
申请日：2013-02-12
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC分类号： C12N15/00 , C12N15/113 , C12N15/1135 , C12N2310/14 , C12N2320/11 , C12N2320/31
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CTNNB1.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对CTNNB1的核苷酸序列的那些。
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