Invention Grant
US09228188B2 Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
有权
抑制铁调素抗菌肽（HAMP）或HAMP相关基因表达的组合物和方法
- Patent Title: Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
- Patent Title (中): 抑制铁调素抗菌肽（HAMP）或HAMP相关基因表达的组合物和方法
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Application No.: US14118489Application Date: 2012-06-21
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Publication No.: US09228188B2Publication Date: 2016-01-05
- Inventor: Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
- Applicant: Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
- Applicant Address: US MA Cambridge
- Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- International Application: PCT/US2012/043603 WO 20120621
- International Announcement: WO2012/177921 WO 20121227
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; A61K31/7105 ; A61K33/26 ; A61K47/48
Abstract:
The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a hepcidin antimicrobial peptide (HAMP) and/or HAMP-related gene, and methods of using the dsRNA to inhibit expression of HAMP and/or HAMP-related genes.
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