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公开(公告)号：US08598335B2
公开(公告)日：2013-12-03
申请号：US13614836
申请日：2012-09-13
Applicant: Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
Inventor： Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
CPC classification number: C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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公开(公告)号：US08344129B2
公开(公告)日：2013-01-01
申请号：US13355879
申请日：2012-01-23
Applicant: Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
Inventor： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
CPC classification number: C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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公开(公告)号：US08293718B2
公开(公告)日：2012-10-23
申请号：US12970268
申请日：2010-12-16
Applicant: Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
Inventor： Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
IPC: C12N15/11
CPC classification number: C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , Y02A50/467 , C12N2310/3521
Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
Abstract translation: 本公开涉及使用治疗有效量的RNAi剂对HSF治疗热休克因子1（HSF1）相关疾病如癌症和病毒性疾病的方法。
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4.发明申请公开(公告)号：US20120225927A1
公开(公告)日：2012-09-06
申请号：US13410262
申请日：2012-03-01
Applicant: Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: A61K31/713 , A61P25/28 , C12N5/071 , C12N15/113
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
Abstract translation: 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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公开(公告)号：US20120122960A1
公开(公告)日：2012-05-17
申请号：US13355879
申请日：2012-01-23
Applicant: Antonin DE FOUGEROLLES , John L. DIENER , Emma HICKMAN , Gregory HINKLE , Stuart MILSTEIN , Anne-Marie PULICHINO , Andrew SPRAGUE
Inventor： Antonin DE FOUGEROLLES , John L. DIENER , Emma HICKMAN , Gregory HINKLE , Stuart MILSTEIN , Anne-Marie PULICHINO , Andrew SPRAGUE
CPC classification number: C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20100120893A1
公开(公告)日：2010-05-13
申请号：US12582669
申请日：2009-10-20
Applicant: Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: A61K31/7088 , C07H21/04 , C12N15/63 , C12N5/10 , A61P43/00
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
Abstract translation: 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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7.发明授权Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes 有权用于抑制载脂蛋白C-III（APOC3）基因表达的组合物和方法公开(公告)号：US09315813B2
公开(公告)日：2016-04-19
申请号：US14125567
申请日：2012-06-21
Applicant: Brian Bettencourt , Kevin Fitzgerald , Stuart Milstein , Martin Maier , Klaus Charisse , Kallanthottathil Rajeev , Satyanarayana Kuchimanchi , Muthiah Manoharan , Tuyen Nguyen
Inventor： Brian Bettencourt , Kevin Fitzgerald , Stuart Milstein , Martin Maier , Klaus Charisse , Kallanthottathil Rajeev , Satyanarayana Kuchimanchi , Muthiah Manoharan , Tuyen Nguyen
IPC: C12N15/11 , C12N15/113
CPC classification number: C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/344 , C12N2310/3515 , C12N2310/3521
Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
Abstract translation: 本发明涉及靶向APOC3基因的双链核糖核酸（dsRNA），以及使用dsRNA抑制APOC3表达的方法。
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公开(公告)号：US08741866B2
公开(公告)日：2014-06-03
申请号：US13410262
申请日：2012-03-01
Applicant: Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
Abstract translation: 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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9.发明申请Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes 有权抑制载脂蛋白C-III（APOC3）基因表达的组成和方法公开(公告)号：US20140113957A1
公开(公告)日：2014-04-24
申请号：US14125567
申请日：2012-06-21
Applicant: Brian Bettencourt , Kevin Fitzgerald , Stuart Milstein , Martin Maier , Klaus Charisse , Rajeev Kallanthottathil , Satyanarayana Kuchimanchi , Muthiah Manoharan , Tuyen Nguyen
Inventor： Brian Bettencourt , Kevin Fitzgerald , Stuart Milstein , Martin Maier , Klaus Charisse , Rajeev Kallanthottathil , Satyanarayana Kuchimanchi , Muthiah Manoharan , Tuyen Nguyen
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/344 , C12N2310/3515 , C12N2310/3521
Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
Abstract translation: 本发明涉及靶向APOC3基因的双链核糖核酸（dsRNA），以及使用dsRNA抑制APOC3表达的方法。
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公开(公告)号：US08623838B2
公开(公告)日：2014-01-07
申请号：US13363504
申请日：2012-02-01
Applicant: Jinyun Chen , Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
Inventor： Jinyun Chen , Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
CPC classification number: C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , Y02A50/467 , C12N2310/3521
Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
Abstract translation: 本公开涉及使用治疗有效量的RNAi剂对HSF治疗热休克因子1（HSF1）相关疾病如癌症和病毒性疾病的方法。
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