Systems, methods and apparatus are disclosed for targeted regeneration of a catalyst device in an exhaust aftertreatment system of an internal combustion engine. The targeted regeneration can include interpreting, initiating, and/or completing a regeneration event for an SCR catalyst or other type of catalyst in response to a catalyst deactivation condition. A catalyst regeneration event includes at least one of exposing the catalyst to a sufficiently high temperature over a time period that removes contaminants from the catalyst and manipulation of the exhaust gas composition to initiate and/or accelerate removal of contaminants from the catalyst.