A calibration circuit for a DCO includes a signal-conditioning module configured for (i) receiving at input an oscillating signal generated by the DCO and a reference signal, both designed to oscillate between a high logic value (“1”) and a low logic value (“0”), and (ii) detecting a respective first and second stable logic value of the reference signal and of the oscillating signal; and a period-to-voltage converter module coupled to the signal-conditioning module and configured for (iii) generating a difference signal identifying a difference between the period of the reference signal and the period of the oscillating signal, and (iv) controlling, on the basis of the difference signal, the DCO so as to conform the duration of the period of the oscillating signal to the duration of the period of the reference signal. Likewise described is a calibration method implemented by the calibration circuit.