A method for enabling full duplex direct mode calls between radios in an N:1 slotting ratio TDMA radio system includes detecting a request for a full duplex direct mode call at a first radio, transmitting in a particular slot of a first recurring time slot of N recurring time slots on a first single frequency one of a call request and a call header identifying the call as a full duplex call. Subsequently transmitting, by the first radio, during a plurality of subsequent first recurring time slots, outbound voice and/or data transmissions. And receiving, during a plurality of second recurring time slots of the N recurring time slots, each second recurring timeslot positioned immediately adjacent a respective first recurring time slot in an interleaved manner, inbound voice and/or data transmissions from the second radio and playing back the inbound voice and/or data transmission at the first radio.