Sensor data having values received from several sensors of a mobile device and response data associated with the sensor data may be used in the determination or training of a predictive model. Received sensor data may be input into the predictive model, and the output of the predictive model may be used in the selection and serving of content items to the mobile device. Data to effect presentation of the selected content item may be outputted to the mobile device to effect presentation. In some instances, the predictive model may be updated using the received plurality of values. The updated predictive model may be used in the selection of a subsequent content item for the mobile device. In other implementations, historical sensor data may be used with the set of received sensor data as input for the predictive model.