Invention Grant
- Patent Title: Inhibition of collagen synthesis
- Patent Title (中): 抑制胶原合成
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Application No.: US14355879Application Date: 2012-11-05
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Publication No.: US09238685B2Publication Date: 2016-01-19
- Inventor: Michael P. Czubryt
- Applicant: University of Manitoba
- Applicant Address: CA Winnipeg
- Assignee: University of Manitoba
- Current Assignee: University of Manitoba
- Current Assignee Address: CA Winnipeg
- Agency: Alchemy-Partners, PC
- International Application: PCT/CA2012/001018 WO 20121105
- International Announcement: WO2013/063692 WO 20130510
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C07H21/00 ; A61P43/00 ; C07K14/495 ; A61K38/17 ; C07K14/47

Abstract:
Therapies and compositions for reducing collagen synthesis in mammalian cells and tissues wherein the targets are scleraxis, sclerax-is-binding sites, receptor-regulated Smads, and/or binding sites for receptor-regulated Smads whereby synergistic interactions between scleraxis proteins and receptor-regulated Smads are reduced, inhibited, interfered with, stopped, and/or prevented thereby reducing, inhibiting and/or interfering with the activation of collagen 1α2 promoter thereby inhibiting collagen production in mammalian cells and tissues. Alternatively, the therapies and compositions may reduce, inhibit, interfere with, stop, and/or prevent binding of the collagen 1α2 promoter to DNA thereby inhibiting expression of the collagen 1α2 gene in mammalian cells and tissues.
Public/Granted literature
- US20140288003A1 INHIBITION OF COLLAGEN SYNTHESIS Public/Granted day:2014-09-25
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