Invention Grant
- Patent Title: Phenylacetamide compound and pharmaceutical containing same
- Patent Title (中): 苯乙酰胺化合物和含有它们的药物
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Application No.: US14427865Application Date: 2013-09-25
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Publication No.: US09242978B2Publication Date: 2016-01-26
- Inventor: Takahisa Ogamino , Shin Tanikawa , Yoshiharu Miyake , Shinsuke Itoh , Yoshikazu Sawada
- Applicant: KOWA COMPANY, LTD.
- Applicant Address: JP Aichi
- Assignee: Kowa Company, Ltd.
- Current Assignee: Kowa Company, Ltd.
- Current Assignee Address: JP Aichi
- Agency: King & Spalding LLP
- Agent Kenneth H. Sonnenfeld; Margaret B. Brivanlou
- Priority: JP2012-211623 20120926
- International Application: PCT/JP2013/005657 WO 20130925
- International Announcement: WO2014/050084 WO 20140403
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D403/12 ; C07D417/12 ; A61K31/4155 ; A61K31/427 ; A61K31/4439 ; A61K31/497 ; C07D417/14

Abstract:
The present invention is to create a compound that selectively activates glucokinase in the liver, and in particular, to provide an agent for treating and preventing diabetes and impaired glucose tolerance, wherein the agent has a low hypoglycemia risk. A compound represented by the formula (1) as shown below, or a salt thereof, or a solvate of the compound or the salt:wherein, in the following formula (1), ring A represents a thiazolyl group, a pyridyl group, a pyrazyl group, or a pyrazolyl group; L represents —(CO)—, —(CS)—, or —SO2—; and R1 represents a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy group, an amino group, a C1-6 alkylamino group, a hydroxyamino group, an N—C1-6 alkylcarbamoyl group, or a group represented by the formula (2) as shown below, wherein R3 represents a C1-6 alkyl group; and R2 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or a carboxyl group. The formulas are shown below:
Public/Granted literature
- US20150218151A1 NOVEL PHENYLACETAMIDE COMPOUND AND PHARMACEUTICAL CONTAINING SAME Public/Granted day:2015-08-06
Information query