This disclosure describes techniques for performing memory transfer operations with a graphics processing unit (GPU) based on a selectable memory transfer mode, and techniques for selecting a memory transfer mode for performing all or part of a memory transfer operation with a GPU. In some examples, the techniques of this disclosure may include selecting a memory transfer mode for performing at least part of a memory transfer operation, and performing, with a GPU, the memory transfer operation based on the selected memory transfer mode. The memory transfer mode may be selected from a set of at least two different memory transfer modes that includes an interleave memory transfer mode and a sequential memory transfer mode. The techniques of this disclosure may be used to improve the performance of GPU-assisted memory transfer operations.