A method for enhancing read performance in a multi-reader two-dimensional magnetic recording system comprising first and second readers includes: receiving first and second analog read signals from the first and second readers, respectively; sampling the first and second analog read signals to generate first and second sampled signals, respectively, each of the first and second sampled signals comprising an integer component, indicative of a value of a corresponding one of the first and second analog read signals, respectively, at an integer multiple of a corresponding sampling period associated therewith, and/or a fractional component, indicative of a value of the corresponding one of the first and second analog read signals, respectively, at an arbitrary point in time between integer multiples of the corresponding sampling period; and combining the integer and/or fractional components of the respective first and second sampled signals to thereby generate a reader offset estimation signal.