Invention Grant
- Patent Title: Tricyclic heterocycle compounds
- Patent Title (中): 三环杂环化合物
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Application No.: US14429923Application Date: 2013-09-20
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Publication No.: US09249157B2Publication Date: 2016-02-02
- Inventor: Weifang Shan , Ashvinikumar V. Gavai , James Aaron Balog
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2013/060831 WO 20130920
- International Announcement: WO2014/047390 WO 20140327
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D498/04 ; A61K31/138 ; A61K31/337 ; A61K31/506 ; A61K31/555 ; A61K31/573 ; A61K31/5513 ; A61K31/553 ; A61K45/06

Abstract:
Disclosed are compounds of Formula (I), wherein: X is O or —NR3; R1 is —CH2CH2CH3, —CH2CF3, —CH2CH2CF3, —CH2CF2CH3, —CH2CH2CH2CF3, —CH2CH2CF2CH3, —CH2CH(CH3)CF3, —CH2CH2CH2F, or CH2(cyclopropyl); R2 is —CH2CH2CH3, —CH2CF3, —CH2CH2CF3, —CH2CF2CH3, —CH2CH2CH2CF3, —CH2CH2CH2F, —CH2CH(CH3)CF3, CH2CH2CF2CH3, —CH2(cyclopropyl), —CH(CH3)(cyclopropyl), phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, pyridinyl, formula (i), formula (ii), formula (iii), formula (iv) or formula (v); Ring A is phenyl or pyridinyl; and R3, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US20150246930A1 TRICYCLIC HETEROCYCLE COMPOUNDS Public/Granted day:2015-09-03
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