A system, method, and computer program product are provided for multi-sample processing. The multi-sample pixel data is received and an encoding state associated with the multi-sample pixel data is determined. Data for one sample of a multi-sample pixel and the encoding state are provided to a processing unit. The one sample of the multi-sample pixel is processed by the processing unit to generate processed data for the one sample that represents processed multi-sample pixel data for all samples of the multi-sample pixel or two or more samples of the multi-sample pixel.