Invention Grant
US09266903B2 Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazole-5-yl)-5,6-dihydrobenzo[F]imidazo [1,2-D][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
有权
2-（4-（2-（1-异丙基-3-甲基-1H-1,2,4-三唑-5-基）-5,6-二氢苯并[F]咪唑并[1,2-D] [1,4]氧氮杂-9-基）-1H-吡唑-1-基）-2-甲基丙酰胺，其制备方法及其药物用途
![Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazole-5-yl)-5,6-dihydrobenzo[F]imidazo [1,2-D][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof](/docs/US/2016-02-23/US09266903B2/abs.jpg.600x600.jpg)
- Patent Title: Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazole-5-yl)-5,6-dihydrobenzo[F]imidazo [1,2-D][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
- Patent Title (中): 2-（4-（2-（1-异丙基-3-甲基-1H-1,2,4-三唑-5-基）-5,6-二氢苯并[F]咪唑并[1,2-D] [1,4]氧氮杂-9-基）-1H-吡唑-1-基）-2-甲基丙酰胺，其制备方法及其药物用途
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Application No.: US14570019Application Date: 2014-12-15
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Publication No.: US09266903B2Publication Date: 2016-02-23
- Inventor: Jeffrey Stults
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Alex Andrus
- Main IPC: A61K31/553
- IPC: A61K31/553 ; C07D498/06 ; A61K45/06 ; C07D498/04
![Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazole-5-yl)-5,6-dihydrobenzo[F]imidazo [1,2-D][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof](/abs-image/US/2016/02/23/US09266903B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
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