Invention Grant
- Patent Title: Selective inhibitors of human corticosteroid synthases
- Patent Title (中): 人类皮质类固醇合酶的选择性抑制剂
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Application No.: US11885605Application Date: 2006-03-02
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Publication No.: US09271963B2Publication Date: 2016-03-01
- Inventor: Rolf Hartmann , Marieke Voets , Ursula Müller-Vieira
- Applicant: Rolf Hartmann , Marieke Voets , Ursula Müller-Vieira
- Applicant Address: DE Saarbrucken
- Assignee: UNIVERSITAT DES SAARLANDES
- Current Assignee: UNIVERSITAT DES SAARLANDES
- Current Assignee Address: DE Saarbrucken
- Agency: Ballard Spahr LLP
- Priority: DE102005009705 20050303; DE102005029372 20050624
- International Application: PCT/EP2006/060410 WO 20060302
- International Announcement: WO2006/092430 WO 20060908
- Main IPC: C07D213/16
- IPC: C07D213/16 ; C07D213/24 ; C07D213/30 ; C07D233/54 ; C07D233/56 ; C07D233/64 ; C07D239/26 ; C07D239/30 ; C07D239/34 ; C07D263/32 ; A61K31/4164 ; A61K31/4406 ; A61K31/4709 ; A61K31/505 ; C07D213/55 ; C07D213/56 ; C07D213/57
Abstract:
The invention relates to compounds for selectively inhibiting human corticosteroid synthases CYP1 1 B1 and CYP1 1 B2, and to the production and use thereof for treating hypercortisolism, diabetes mellitus, hyperaldosteronism, cardiac insufficiency, myocardial fibrosis, depression, age-related cognitive decline and metabolic syndrome.
Public/Granted literature
- US20090221591A1 Selective Inhibitors of Human Corticosteroid Synthases Public/Granted day:2009-09-03
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