Invention Grant
- Patent Title: Acute hepatic insufficiency depressant and method for evaluating drug efficacy thereof
- Patent Title (中): 急性肝功能不全抑制剂及其药效的评价方法
-
Application No.: US14112490Application Date: 2012-04-18
-
Publication No.: US09272018B2Publication Date: 2016-03-01
- Inventor: Hirohito Tsubouchi , Akio Ido , Tsutomu Chiba , Akira Shimizu
- Applicant: Hirohito Tsubouchi , Akio Ido , Tsutomu Chiba , Akira Shimizu
- Applicant Address: JP Kyoto
- Assignee: Kyoto University
- Current Assignee: Kyoto University
- Current Assignee Address: JP Kyoto
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2011-092516 20110418
- International Application: PCT/JP2012/060505 WO 20120418
- International Announcement: WO2012/144535 WO 20121026
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/475 ; A61K39/395 ; G01N33/68
Abstract:
The present invention provides a therapeutic agent for acute liver failure containing a hepatocyte growth factor (HGF), particularly an agent for treating fulminant hepatitis or late onset hepatic failure or suppression of progression of acute liver failure without hepatic coma to fulminant hepatitis or late onset hepatic failure. The present invention also provides a method for evaluating the efficacy of HGF including measuring the amount of α-fetoprotein (liver regeneration biomarker) and/or soluble Fas (anti-apoptotic biomarker) in a sample obtained from a liver injury patient administered with HGF.
Public/Granted literature
- US20140234341A1 ACUTE HEPATIC INSUFFICIENCY DEPRESSANT AND METHOD FOR EVALUATING DRUG EFFICACY THEREOF Public/Granted day:2014-08-21
Information query
IPC分类:
