发明授权
- 专利标题： PEGylated recombinant human growth hormone compounds
- 专利标题（中）： 聚乙二醇化重组人生长激素化合物
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申请号： US12990101申请日： 2009-04-29
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公开(公告)号： US09272048B2公开(公告)日： 2016-03-01
- 发明人: Harald Rau , Susanne Kinderman , Torben Lebmann , Grethe Norskov Rasmussen , Ulrich Hersel , Thomas Wegge , Kennett Sprogoe
- 申请人： Harald Rau , Susanne Kinderman , Torben Lebmann , Grethe Norskov Rasmussen , Ulrich Hersel , Thomas Wegge , Kennett Sprogoe
- 申请人地址： DK Hellerup
- 专利权人： Ascendis Pharma Growth Disorders Division A/S
- 当前专利权人： Ascendis Pharma Growth Disorders Division A/S
- 当前专利权人地址： DK Hellerup
- 代理机构： Frommer Lawrence & Haug LLP
- 优先权： EP08155408 20080429; EP08162865 20080822; EP08167289 20081022
- 国际申请： PCT/EP2009/055194 WO 20090429
- 国际公布： WO2009/133137 WO 20091105
- 主分类号： A61K38/27
- IPC分类号： A61K38/27 ; C07K14/61 ; A61K47/48
摘要：
A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
公开/授权文献
- US20110112021A1 PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS 公开/授权日：2011-05-12
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