Invention Grant
US09273040B2 Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
有权
在电压门控钠通道中具有选择性活性的苯并恶唑啉酮化合物
- Patent Title: Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
- Patent Title (中): 在电压门控钠通道中具有选择性活性的苯并恶唑啉酮化合物
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Application No.: US14353488Application Date: 2012-10-26
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Publication No.: US09273040B2Publication Date: 2016-03-01
- Inventor: Mark E. Layton , Joseph E. Pero , Hannah Fiji , Michael J. Kelly, III , Pablo de Leon , Michael A. Rossi , Kevin F. Gilbert , Anthony J. Roecker , Zhijian Zhao , Swati I P. Mercer , Scott Wolkenberg , James Mulhearn , Lianyun Zhao , Dansu Li
- Applicant: Mark E. Layton , Joseph E. Pero , Hannah Fiji , Michael J. Kelly, III , Pablo de Leon , Michael A. Rossi , Kevin F. Gilbert , Anthony J. Roecker , Zhijian Zhao , Swati I P. Mercer , Scott Wolkenberg , James Mulhearn , Lianyun Zhao , Dansu Li
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; John C. Todaro
- International Application: PCT/US2012/062207 WO 20121026
- International Announcement: WO2013/063459 WO 20130502
- Main IPC: A61K31/00
- IPC: A61K31/00 ; C07D417/12 ; C07D417/14 ; C07D451/02 ; C07D471/04 ; C07D491/107 ; C07D493/10
Abstract:
Disclosed are compounds of Formula (A) or a salt thereof, wherein “Het”, Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (A) or their salts, and methods of treating neuropathic pain disorders using the same.
Public/Granted literature
- US20140303143A1 BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS Public/Granted day:2014-10-09
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