Invention Grant
US09273074B2 Formylpyrrole-based heterocycles for nucleic acid attachment to supports
有权
用于核酸附着于载体的甲酰基吡咯基杂环
- Patent Title: Formylpyrrole-based heterocycles for nucleic acid attachment to supports
- Patent Title (中): 用于核酸附着于载体的甲酰基吡咯基杂环
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Application No.: US14512181Application Date: 2014-10-10
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Publication No.: US09273074B2Publication Date: 2016-03-01
- Inventor: Ryan Christopher Smith , Randall Smith , Xiaodong Zhao
- Applicant: Illumina, Inc.
- Applicant Address: US CA San Diego
- Assignee: Illumina, Inc.
- Current Assignee: Illumina, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C07F9/6503
- IPC: C07F9/6503 ; C07F9/6506 ; A61K31/675 ; C07F9/572 ; C07H21/00

Abstract:
A compound has Formula I: A, B, C, D, W, X, Y, and Z are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, aryl, aldehyde, protected aldehyde, CH, N, O, S, null, and bond; Q is selected from aldehyde, protected aldehyde, and null, at least one of A, B, C, D, W, X, Y, Z, or Q is an aldehyde or protected aldehyde; the bonds between each of A-B, B-C, C-D, W-X, X-Y, and Y-Z are selected from single bond, double bond, triple bond, and no bond; L is a linker selected from a C1-C12 alkyl, aralkyl, and aryl, any of which is optionally substituted; one or more methylene unit (CH2) of the C1-C12 alkyl is optionally replaced by any combination of oxygen, carbonyl(C═O), and NH; and R1 and R2 are independently selected from —NR3R4, halogen, C1-C8 alkoxy, aralkoxy, alkenyloxy, alkynyloxy, and OCH2CH2CN; R3 and R4 are independently a C1-C4, straight chain or branched alkyl group.
Public/Granted literature
- US20150031833A1 FORMYLPYRROLE-BASED HETEROCYCLES FOR NUCLEIC ACID ATTACHMENT TO SUPPORTS Public/Granted day:2015-01-29
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