发明授权
- 专利标题： Solid state synthesis hydroxyl radicals for high throughput structure determination of proteins and nucleic acids by oxidative footprinting
- 专利标题（中）： 固态合成羟基自由基用于通过氧化足迹测定蛋白质和核酸的高通量结构
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申请号： US13063833申请日： 2009-08-24
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公开(公告)号： US09279814B2公开(公告)日： 2016-03-08
- 发明人: Michael Brenowitz , Jorg Schlatterer
- 申请人： Michael Brenowitz , Jorg Schlatterer
- 申请人地址： US NY Bronx
- 专利权人： Albert Einstein College of Medicine, Inc.
- 当前专利权人： Albert Einstein College of Medicine, Inc.
- 当前专利权人地址： US NY Bronx
- 代理机构： Amster, Rothstein & Ebenstein LLP
- 国际申请： PCT/US2009/004804 WO 20090824
- 国际公布： WO2010/030321 WO 20100318
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; B01L3/00 ; C07H21/00
摘要：
The present invention generally relates to an apparatus for structural mapping of a macromolecule comprising an amount of persulfide effective to generate hydroxyl radicals upon contact with an aqueous solution. The present invention further relates to methods for structural mapping a macromolecule in an aqueous solution and methods for structural mapping a plurality of macromolecules in parallel, wherein each macromolecule is in a separate aqueous solution.
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