A communication system to route telephony signals based on OLI. The communication system includes a telephony signaling system and a call processing system. The telephony signaling system receives a first signaling message over an originating line indicating a telephony number and in response, generates and transfers a second signaling message indicating the telephony number and the OLI for delivery to a call processing system. The call processing system receives the second signaling message, and in response, processes the telephony number to identify a RespOrg. The call processing system processes the OLI based on the identified RespOrg to select a CIC. Call processing system generates and transfers a third signaling message indicating the selected CIC for delivery to the telephony signaling system. The telephony signaling system receives the third signaling message, and in response, generates and transfers a fourth signaling message for delivery to a telephony network based on the selected CIC.