发明授权
US09295650B2 Functional, cross-linked nanostructures for tandem optical imaging and therapy
有权
用于串联光学成像和治疗的功能性交联纳米结构
- 专利标题： Functional, cross-linked nanostructures for tandem optical imaging and therapy
- 专利标题（中）： 用于串联光学成像和治疗的功能性交联纳米结构
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申请号： US13697149申请日： 2011-11-17
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公开(公告)号： US09295650B2公开(公告)日： 2016-03-29
- 发明人: William L. Neumann , Richard B. Dorshow , John N. Freskos , Karen L. Wooley , Nam S. Lee , Yun Lin , Guorong Sun
- 申请人： William L. Neumann , Richard B. Dorshow , John N. Freskos , Karen L. Wooley , Nam S. Lee , Yun Lin , Guorong Sun
- 申请人地址： US MO Hazelwood US TX College Station US MI St. Louis
- 专利权人： Mallinckrodt LLC,The Texas A&M University System,Washington University
- 当前专利权人： Mallinckrodt LLC,The Texas A&M University System,Washington University
- 当前专利权人地址： US MO Hazelwood US TX College Station US MI St. Louis
- 国际申请： PCT/US2011/036392 WO 20111117
- 国际公布： WO2011/143524 WO 20111117
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; A61K9/14 ; A61K9/00 ; A61K9/107 ; A61K9/51 ; A61K31/20 ; A61K31/70 ; A61K38/16 ; A61K38/22 ; A61K39/395 ; A61M5/00
摘要：
The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.