公开(公告)号：US20240139113A1

公开(公告)日：2024-05-02

申请号：US17975968

申请日：2022-10-28

Applicant: Hung-Yun Lin

Inventor： Hung-Yun Lin

IPC: A61K9/51 ,  A61K9/00 ,  A61K9/127 ,  A61K31/704 ,  A61K47/28

CPC classification number: A61K9/5123 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/704 ,  A61K47/28

Abstract: The present disclosure provides a lipid nanoparticle and uses of the lipid nanoparticle for treating cancer, targeting integrin αvβ3, anti-angiogenesis to prevent cancer metastasis and reducing the cytotoxicity of anti-cancer drugs to normal cells. In addition, since it can inhibit angiogenesis, it also can be used in vascular related diseases. The lipid nanoparticle provides targeting cell surface integrin αvβ3, the nano-liposome specific against digestion system-related cancers locally and systemically. The lipid nanoparticle of the present disclosure would target cancer cells instead of normal cells. Even normal cells contain integrin αvβ3, however, the lipid nanoparticle of the present disclosure only recognizes the conformation of integrin αvβ3 on the cancer cells. The lipid nanoparticle of the present disclosure can equip with other targeting molecules, payload with other anti-cancer drugs, and can combine with radiation therapy and reduce radiation therapeutic threshold.

公开(公告)号：US10912936B2

公开(公告)日：2021-02-09

申请号：US16148701

申请日：2018-10-01

Applicant: National Formosa University ,  National Taiwan University Hospital Yun-Lin Branch

Inventor： Sung-An Lin ,  I-En Lin ,  Feng-Jung Yang ,  Hao-Ting Chiang

IPC: A61M39/18 ,  A61M1/28 ,  A61M39/10 ,  A61M39/20

Abstract: A tube-docking holding device includes a first connector bracket and a second connector bracket. The first connector bracket includes two shells. When the two shells are closed, a first accommodation space is surrounded for fixing a portion of a first connector assembly of a catheter. The second connector bracket includes a base body and a cover body. The base body includes a first inner shell and a first outer shell. The cover body includes a second inner shell and a second outer shell. When the cover body and the base body are closed, the first inner shell and the second inner shell surround and define a second accommodation space for fixing a portion of a second connector assembly of a dialysate tube. An interconnected guiding space is formed between the first inner shell and the first outer shell and between the second inner shell and the second outer shell.

公开(公告)号：USD891923S1

公开(公告)日：2020-08-04

申请号：US29625709

申请日：2017-11-12

Applicant: Yun Lin

Designer： Yun Lin

公开(公告)号：USD852037S1

公开(公告)日：2019-06-25

申请号：US29623388

申请日：2017-10-25

Applicant: Yun Lin

Designer： Yun Lin

公开(公告)号：US10273973B2

公开(公告)日：2019-04-30

申请号：US13578163

申请日：2011-02-03

Applicant: Xinqian Zheng ,  Yun Lin ,  Yangjun Zhang ,  Mingyang Yang ,  Takahiro Bamba ,  Hideaki Tamaki

Inventor： Xinqian Zheng ,  Yun Lin ,  Yangjun Zhang ,  Mingyang Yang ,  Takahiro Bamba ,  Hideaki Tamaki

IPC: F04D17/10 ,  F04D29/42 ,  F04D29/68

Abstract: A centrifugal compressor includes an asymmetric self-recirculating casing treatment that includes, on an inner face of a casing 10, a suction ring groove 1, a ring guide channel 2 and a back-flow ring groove 3 to form a self-recirculating channel. An axial distance Sr from an upstream end face of the suction ring groove 1 to an impeller full blade leading edge 4 or a width br of the suction ring groove 1 is represented as A·sin(α+θ0)+A0 and is distributed in a sinusoidal shape in a circumferential direction, an initial phase angle θ0 is in a range of 0°≤θ0≤360°, and a circumferential angle α of the casing 10 has a definition range of θ0≤α≤θ0+360°. In the expression, A denotes amplitude of distribution of the axial distance Sr or the width br, and A0 denotes an average of the axial distance Sr or the width br.

公开(公告)号：US09816522B2

公开(公告)日：2017-11-14

申请号：US13578188

申请日：2011-02-03

Applicant: Xinqian Zheng ,  Yun Lin ,  Yangjun Zhang ,  Mingyang Yang ,  Takahiro Bamba ,  Hideaki Tamaki

Inventor： Xinqian Zheng ,  Yun Lin ,  Yangjun Zhang ,  Mingyang Yang ,  Takahiro Bamba ,  Hideaki Tamaki

IPC: F04D17/16 ,  F04D29/42 ,  F04D29/68

CPC classification number: F04D29/4213 ,  F04D29/685

Abstract: A centrifugal compressor has a casing 7. In the casing 7 is formed a back-flow channel 9 to return fluid from a downstream position of an impeller full blade leading edge 6a to an upstream position of the impeller full blade leading edge 6a. The back-flow channel 9 includes a suction ring groove 9a and a back-flow ring groove 9b. The suction ring groove opens at the downstream position on the inner face 7a of the casing 7, and extends in the circumferential direction. The back-flow ring groove opens at the upstream position on the inner face 7a, and extends in the circumferential direction. Distribution in the circumferential direction of the axial-direction position of the suction ring groove 9a or a width of the suction ring groove 9a is asymmetric with reference to the rotation axis.

公开(公告)号：US09295650B2

公开(公告)日：2016-03-29

申请号：US13697149

申请日：2011-11-17

Applicant: William L. Neumann ,  Richard B. Dorshow ,  John N. Freskos ,  Karen L. Wooley ,  Nam S. Lee ,  Yun Lin ,  Guorong Sun

Inventor： William L. Neumann ,  Richard B. Dorshow ,  John N. Freskos ,  Karen L. Wooley ,  Nam S. Lee ,  Yun Lin ,  Guorong Sun

IPC: A61K49/00 ,  A61K9/14 ,  A61K9/00 ,  A61K9/107 ,  A61K9/51 ,  A61K31/20 ,  A61K31/70 ,  A61K38/16 ,  A61K38/22 ,  A61K39/395 ,  A61M5/00

CPC classification number: A61K41/0057 ,  A61K9/0092 ,  A61K9/1075 ,  A61K9/146 ,  A61K9/5138 ,  A61K9/5192 ,  A61K31/20 ,  A61K31/337 ,  A61K31/351 ,  A61K31/70 ,  A61K31/704 ,  A61K38/08 ,  A61K38/16 ,  A61K38/22 ,  A61K45/06 ,  A61K47/6911 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/0082 ,  A61K49/0093 ,  A61M5/007 ,  A61K2300/00

Abstract: The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.

Abstract translation: 本发明提供包含光学功能交联的超分子结构和用于串联光学成像和治疗的组合物的光学剂。 本发明的超分子结构和组件包括光学功能的壳交联胶束，其中通过引入一个或多个包含一个或多个光活性部分的连接基团来实现光学官能团。 本发明还包括使用本发明的一种或多种光学剂的成像和治疗方法，其包括具有相关治疗剂的光学功能性壳交联胶束。

公开(公告)号：US20160083605A1

公开(公告)日：2016-03-24

申请号：US14889047

申请日：2013-05-08

Applicant: Shijun FENG ,  Yun LIN

Inventor： Shijun FENG ,  Yun LIN

IPC: C09D127/12 ,  D06M11/79 ,  D06M15/256

CPC classification number: C09D127/12 ,  C08K3/22 ,  C08K3/36 ,  C08K2003/2227 ,  C08K2003/2241 ,  C08K2003/2296 ,  C09D5/1668 ,  D06M11/79 ,  D06M15/248 ,  D06M15/256 ,  D06M23/08 ,  D06M2101/06 ,  D06M2101/20 ,  D06M2101/24 ,  D06M2101/34 ,  D06M2200/11 ,  D06M2200/12

Abstract: Disclosed water and oil repellent coatings for textile fabrics having a low surface energy portion having a polyolefin having a Rf of 4 or less, and a nanometer portion which has nanoparticles. Also disclosed coated fabrics, as well as methods for making the coated fabrics.

Abstract translation: 公开了具有低表面能部分的织物的防水防油涂料，其具有Rf为4或更小的聚烯烃和具有纳米颗粒的纳米部分。 还公开了涂覆织物，以及制造涂覆织物的方法。

公开(公告)号：US09180107B2

公开(公告)日：2015-11-10

申请号：US12751375

申请日：2010-03-31

Applicant: Hung-Yun Lin ,  Faith B. Davis ,  Paul J. Davis ,  Shaker A. Mousa

Inventor： Hung-Yun Lin ,  Faith B. Davis ,  Paul J. Davis ,  Shaker A. Mousa

IPC: A01N59/22 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C12P21/08 ,  A61K31/192 ,  A61K45/06 ,  A61K47/48

CPC classification number: A61K31/192 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6921 ,  A61K47/6935 ,  A61K47/6937 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for treating cancer by increasing the inhibitory effect of cetuximab on HIF1α expression by administering cetuximab in combination with anti-angiogenic thyroid hormone analogs such as tetrac or triac.

Abstract translation: 本文提供了通过施用西妥昔单抗联合抗血管生成甲状腺激素类似物如四或三联报来增加西妥昔单抗对HIF1α表达的抑制作用来治疗癌症的组合物和方法。

公开(公告)号：US09151297B2

公开(公告)日：2015-10-06

申请号：US13578101

申请日：2011-02-03

Applicant: Xinqian Zheng ,  Yun Lin ,  Yangjun Zhang ,  Mingyang Yang ,  Takahiro Bamba ,  Hideaki Tamaki

Inventor： Xinqian Zheng ,  Yun Lin ,  Yangjun Zhang ,  Mingyang Yang ,  Takahiro Bamba ,  Hideaki Tamaki

IPC: F04D29/42 ,  F04D29/68

CPC classification number: F04D29/4213 ,  F04D29/685 ,  F05D2250/73

Abstract: A centrifugal compressor includes an asymmetric self-recirculating casing treatment that includes, on an inner face of a casing 10, a suction ring groove 1, a ring guide channel 2 and a back-flow ring groove 3 to form a self-recirculating channel. A position or a width of the suction ring groove 1 is distributed in an arc shape in a circumferential direction, and the arc has a center angle α in a range of 0

Abstract translation: 离心压缩机包括不对称的自再循环壳体处理，其在壳体10的内表面上包括吸入环槽1，环形引导通道2和回流环槽3，以形成自再循环通道。 吸入环槽1的位置或宽度在圆周方向上分布成圆弧状，电弧的中心角α为0 <α<0.01; 30°的范围。