发明授权
US09296697B2 Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors
有权
杂芳基取代的胍化合物及其作为5-HT 5受体的结合伴侣的用途
- 专利标题： Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors
- 专利标题（中）： 杂芳基取代的胍化合物及其作为5-HT 5受体的结合伴侣的用途
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申请号： US11990937申请日： 2006-08-23
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公开(公告)号： US09296697B2公开(公告)日： 2016-03-29
- 发明人: Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Charles W. Hutchins , Francisco Javier Garcia-Ladona , Wolfgang Wernet , Alfred Hahn
- 申请人： Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Charles W. Hutchins , Francisco Javier Garcia-Ladona , Wolfgang Wernet , Alfred Hahn
- 申请人地址： US IL Abbott Park DE Wiesbaden
- 专利权人： Abbott Laboratories,AbbVie Deutschland GmbH & Co. KG
- 当前专利权人： Abbott Laboratories,AbbVie Deutschland GmbH & Co. KG
- 当前专利权人地址： US IL Abbott Park DE Wiesbaden
- 代理机构： Michael Best & Friedrich LLP
- 代理商 Lisa V. Mueller
- 优先权： DE102006005915 20060209
- 国际申请： PCT/EP2006/008279 WO 20060823
- 国际公布： WO2007/022964 WO 20070301
- 主分类号： C07D213/75
- IPC分类号： C07D213/75 ; C07D213/84 ; C07D213/85 ; C07D215/38 ; C07D217/22 ; C07D239/42 ; C07D409/04 ; A61K31/44 ; A61K31/47 ; A61K31/505
摘要：
The invention relates to the hetaryl-substituted guanidine compounds of general formula (I), enantiomeres, diastereomeres and/or tautomeres thereof, in addition to the pharmaceutically acceptable salts thereof and the prodrugs of the known compounds. The invention also relates to the use of said hetaryl-substituted guanidine compounds as binding partners for 5-HT5-receptors for treating and/or for the prophylaxis of illnesses which are modulated by a 5-HT5-receptor activity, in particular, for treating and/or for the prophylaxis of neurodegenerative and neuropsychiatric disorders, and signs, symptoms and dysfunctions associated with said disorders.
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