Some demonstrative embodiments include apparatuses, systems and/or methods of protecting domains of a multimode wireless radio transceiver. For example, an apparatus may include a protection domain controller (PDC) to restrict access of a configuration software to a protection domain of a plurality of protection domains of a multimode wireless radio transceiver based on a security level of the configuration software, wherein the protection domain includes one or more radio configuration parameters of the multimode wireless radio transceiver.