Invention Grant
US09309195B2 Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-hepatanoic acid
有权
[R-（R *，R *）] - 2-（4-氟苯基） - （bgr），δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-乙酸
![Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-hepatanoic acid](/docs/US/2016-04-12/US09309195B2/abs.jpg.600x600.jpg)
- Patent Title: Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-hepatanoic acid
- Patent Title (中): [R-（R *，R *）] - 2-（4-氟苯基） - （bgr），δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-乙酸
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Application No.: US14716361Application Date: 2015-05-19
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Publication No.: US09309195B2Publication Date: 2016-04-12
- Inventor: Joseph Francis Krzyzaniak , Jason Albert Leonard
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent Francis J. Tinney
- Main IPC: C07D207/34
- IPC: C07D207/34 ; C07D295/037 ; C07C211/07 ; C07C215/08 ; C07C229/26 ; C07D295/027
![Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-hepatanoic acid](/abs-image/US/2016/04/12/US09309195B2/abs.jpg.150x150.jpg)
Abstract:
Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.
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