Invention Grant
- Patent Title: Process for making hydroxylated cyclopentylpyrimidine compounds
- Patent Title (中): 制备羟基化环戊基嘧啶化合物的方法
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Application No.: US14401091Application Date: 2013-05-17
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Publication No.: US09309204B2Publication Date: 2016-04-12
- Inventor: Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , Keith L. Spencer , Peter J. Stengel
- Applicant: Array BioPharma Inc. , Genentech, Inc.
- Applicant Address: US CO Boulder US CA South San Francisco
- Assignee: ARRAY BIOPHARMA INC.,GENENTECH, INC.
- Current Assignee: ARRAY BIOPHARMA INC.,GENENTECH, INC.
- Current Assignee Address: US CO Boulder US CA South San Francisco
- Agency: Viksnins Harris & Padys PLLP
- International Application: PCT/US2013/041624 WO 20130517
- International Announcement: WO2013/173736 WO 20131121
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D239/70 ; C07D239/42
Abstract:
The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
Public/Granted literature
- US20150099881A1 PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS Public/Granted day:2015-04-09
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