Radio frequency (RF) receivers having whitened digital frame processing and related methods are disclosed. Disclosed embodiments whiten frequency domain interference generated periodic current pulses from by digital frame processing by applying a variable time delay to the frame control signals that initiate digital frame processing. For one embodiment, the variable time delay is achieved by waiting a variable number of digital clock cycles for each digital frame processing cycle. Still further, a variable number of no operation (NO-OP) cycles can be performed at the beginning of each frame processing cycle to provide the variable time delay for the variable number of digital clock cycles. Other variable time delay techniques could also be utilized while still taking advantage of the whitened digital frame processing embodiments described herein.