Invention Grant
US09315813B2 Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
有权
用于抑制载脂蛋白C-III（APOC3）基因表达的组合物和方法
- Patent Title: Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
- Patent Title (中): 用于抑制载脂蛋白C-III（APOC3）基因表达的组合物和方法
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Application No.: US14125567Application Date: 2012-06-21
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Publication No.: US09315813B2Publication Date: 2016-04-19
- Inventor: Brian Bettencourt , Kevin Fitzgerald , Stuart Milstein , Martin Maier , Klaus Charisse , Kallanthottathil Rajeev , Satyanarayana Kuchimanchi , Muthiah Manoharan , Tuyen Nguyen
- Applicant: Brian Bettencourt , Kevin Fitzgerald , Stuart Milstein , Martin Maier , Klaus Charisse , Kallanthottathil Rajeev , Satyanarayana Kuchimanchi , Muthiah Manoharan , Tuyen Nguyen
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc
- Current Assignee: Alnylam Pharmaceuticals, Inc
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- International Application: PCT/US2012/043642 WO 20120621
- International Announcement: WO2012/177947 WO 20121227
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113
Abstract:
The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
Public/Granted literature
- US20140113957A1 Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes Public/Granted day:2014-04-24
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