Invention Grant
US09315848B2 Volatile organic compounds for detecting cell dysplasia and genetic alterations associated with lung cancer
有权
用于检测与肺癌相关的细胞发育异常和遗传改变的挥发性有机化合物
- Patent Title: Volatile organic compounds for detecting cell dysplasia and genetic alterations associated with lung cancer
- Patent Title (中): 用于检测与肺癌相关的细胞发育异常和遗传改变的挥发性有机化合物
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Application No.: US13817285Application Date: 2011-08-17
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Publication No.: US09315848B2Publication Date: 2016-04-19
- Inventor: Hossam Haick , Nir Peled
- Applicant: Hossam Haick , Nir Peled
- Applicant Address: IL Haifa US CO Denver
- Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.,THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
- Current Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.,THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
- Current Assignee Address: IL Haifa US CO Denver
- Agency: Browdy and Neimark, PLLC
- International Application: PCT/IL2011/000667 WO 20110817
- International Announcement: WO2012/023138 WO 20120223
- Main IPC: C12Q1/02
- IPC: C12Q1/02 ; C12Q1/48 ; G01N30/00 ; H01J49/00 ; C12Q1/68 ; G01N33/574 ; G01N30/88
Abstract:
The present invention provides methods of identifying a genetic abnormality such as mutation in EGFR or KRAS or ALK which is associated with the management of lung cancer or diagnosing, prognosing or monitoring the treatment of pre-cancerous conditions of the lung, such as bronchial dysplasia or atypical alveolar hyperplasia (AAH), through the detection of at least one volatile organic compound indicative of these states.
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