Invention Grant
- Patent Title: Quinazoline compounds, method for preparing the same and use thereof
- Patent Title (中): 喹唑啉化合物,其制备方法及其应用
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Application No.: US14103662Application Date: 2013-12-11
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Publication No.: US09321762B2Publication Date: 2016-04-26
- Inventor: Mann-Yan Kuo , Chu-Bin Liao , Shao-Zheng Peng , Shih-Chieh Yen , Nan-Horng Lin
- Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
- Applicant Address: TW New Taipei
- Assignee: Development Center for Biotechnology
- Current Assignee: Development Center for Biotechnology
- Current Assignee Address: TW New Taipei
- Agency: Osha Liang LLP
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D239/94 ; C07D401/04 ; C07D403/04

Abstract:
A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) wherein G is a heteroaryl, heterocyclic or alkyne; X is N or CH; L1 is —N(R7)—, —O—, —C(S)—, —C(O)—, or —S—; L2 is —N(R8)— or —O—; R1 and R2 are independently hydrogen, halogen, hydroxyl, amino, cyano, nitro, carboxy, C1-C4 alkoxy, C1-C4 alkoxy C1-C4 alkoxy, N,N—(C1-C4 dialkyl)amino C1-C4 alkoxy, N—(C1-C4 alkyl)amino C1-C4 alkoxy, C1-C4 alkanoyl, C1-C4 alkanoyloxy, N—(C1-C4 alkyl)amino, N,N—(C1-C4 dialkyl)amino, C1-C4 alkanoyl amino, or heterocyclyl, wherein C1-C4 alkyl is optionally substituted with one or more substituents selected from fluorine and chlorine; R3, R4 and R5 are independently hydrogen, fluorine or chlorine; R6 is C1-C4 alkyl or aryl, which is optionally substituted with one or more substituents selected from halogen, hydroxyl, amino, cyano, nitro; or R6 and R8 form a 5-6 membered cyclyl or heterocyclyl.
Public/Granted literature
- US20150158854A1 QUINAZOLINE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF Public/Granted day:2015-06-11
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