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    QUINAZOLINE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF
    1.
    发明申请
    QUINAZOLINE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF 有权
    喹唑啉化合物，其制备方法和用途

    公开(公告)号：US20150158854A1

    公开(公告)日：2015-06-11

    申请号：US14103662

    申请日：2013-12-11

    Applicant: Development Center For Biotechnology

    Inventor： Mann-Yan Kuo ,  Chu-Bin Liao ,  Shao-Zheng Peng ,  Shih-Chieh Yen ,  Nan-Horng Lin

    IPC: C07D417/14 ,  C07D403/04 ,  C07D239/94 ,  C07D401/04

    CPC classification number: C07D417/14 ,  C07D239/94 ,  C07D401/04 ,  C07D403/04

    Abstract: A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) wherein G is a heteroaryl, heterocyclic or alkyne; X is N or CH; L1 is —N(R7)—, —O—, —C(S)—, —C(O)—, or —S—; L2 is —N(R8)— or —O—; R1 and R2 are independently hydrogen, halogen, hydroxyl, amino, cyano, nitro, carboxy, C1-C4 alkoxy, C1-C4 alkoxy C1-C4 alkoxy, N,N—(C1-C4 dialkyl)amino C1-C4 alkoxy, N—(C1-C4 alkyl)amino C1-C4 alkoxy, C1-C4 alkanoyl, C1-C4 alkanoyloxy, N—(C1-C4 alkyl)amino, N,N—(C1-C4 dialkyl)amino, C1-C4 alkanoyl amino, or heterocyclyl, wherein C1-C4 alkyl is optionally substituted with one or more substituents selected from fluorine and chlorine; R3, R4 and R5 are independently hydrogen, fluorine or chlorine; R6 is C1-C4 alkyl or aryl, which is optionally substituted with one or more substituents selected from halogen, hydroxyl, amino, cyano, nitro; or R6 and R8 form a 5-6 membered cyclyl or heterocyclyl.

    Abstract translation: 一种用于治疗具有式（I）结构的蛋白激酶相关疾病或病症的化合物，其中G是杂芳基，杂环或炔基; X为N或CH; L 1是-N（R 7） - ， - O - ， - C（S） - ， - C（O） - 或-S-; L2是-N（R8） - 或-O-; R1和R2独立地是氢，卤素，羟基，氨基，氰基，硝基，羧基，C1-C4烷氧基，C1-C4烷氧基C1-C4烷氧基，N，N-（C1-C4二烷基）氨基C1-C4烷氧基，N - （C 1 -C 4烷基）氨基C 1 -C 4烷氧基，C 1 -C 4烷酰基，C 1 -C 4烷酰氧基，N-（C 1 -C 4烷基）氨基，N，N-（C 1 -C 4二烷基）氨基，C 1 -C 4烷酰基氨基 或杂环基，其中C 1 -C 4烷基任选被一个或多个选自氟和氯的取代基取代; R3，R4和R5独立地是氢，氟或氯; R6是C1-C4烷基或芳基，其任选被一个或多个选自卤素，羟基，氨基，氰基，硝基的取代基取代; 或R6和R8形成5-6元环基或杂环基。

    Quinazoline compounds, method for preparing the same and use thereof
    4.
    发明授权
    Quinazoline compounds, method for preparing the same and use thereof 有权
    喹唑啉化合物，其制备方法及其应用

    公开(公告)号：US09321762B2

    公开(公告)日：2016-04-26

    申请号：US14103662

    申请日：2013-12-11

    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

    Inventor： Mann-Yan Kuo ,  Chu-Bin Liao ,  Shao-Zheng Peng ,  Shih-Chieh Yen ,  Nan-Horng Lin

    IPC: C07D417/14 ,  C07D239/94 ,  C07D401/04 ,  C07D403/04

    CPC classification number: C07D417/14 ,  C07D239/94 ,  C07D401/04 ,  C07D403/04

    Abstract: A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) wherein G is a heteroaryl, heterocyclic or alkyne; X is N or CH; L1 is —N(R7)—, —O—, —C(S)—, —C(O)—, or —S—; L2 is —N(R8)— or —O—; R1 and R2 are independently hydrogen, halogen, hydroxyl, amino, cyano, nitro, carboxy, C1-C4 alkoxy, C1-C4 alkoxy C1-C4 alkoxy, N,N—(C1-C4 dialkyl)amino C1-C4 alkoxy, N—(C1-C4 alkyl)amino C1-C4 alkoxy, C1-C4 alkanoyl, C1-C4 alkanoyloxy, N—(C1-C4 alkyl)amino, N,N—(C1-C4 dialkyl)amino, C1-C4 alkanoyl amino, or heterocyclyl, wherein C1-C4 alkyl is optionally substituted with one or more substituents selected from fluorine and chlorine; R3, R4 and R5 are independently hydrogen, fluorine or chlorine; R6 is C1-C4 alkyl or aryl, which is optionally substituted with one or more substituents selected from halogen, hydroxyl, amino, cyano, nitro; or R6 and R8 form a 5-6 membered cyclyl or heterocyclyl.

    Abstract translation: 一种用于治疗具有式（I）结构的蛋白激酶相关疾病或病症的化合物，其中G是杂芳基，杂环或炔基; X为N或CH; L 1是-N（R 7） - ， - O - ， - C（S） - ， - C（O） - 或-S-; L2是-N（R8） - 或-O-; R1和R2独立地是氢，卤素，羟基，氨基，氰基，硝基，羧基，C1-C4烷氧基，C1-C4烷氧基C1-C4烷氧基，N，N-（C1-C4二烷基）氨基C1-C4烷氧基，N - （C 1 -C 4烷基）氨基C 1 -C 4烷氧基，C 1 -C 4烷酰基，C 1 -C 4烷酰氧基，N-（C 1 -C 4烷基）氨基，N，N-（C 1 -C 4二烷基）氨基，C 1 -C 4烷酰基氨基 或杂环基，其中C 1 -C 4烷基任选被一个或多个选自氟和氯的取代基取代; R3，R4和R5独立地是氢，氟或氯; R6是C1-C4烷基或芳基，其任选被一个或多个选自卤素，羟基，氨基，氰基，硝基的取代基取代; 或R6和R8形成5-6元环基或杂环基。

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