Invention Grant
- Patent Title: Dermcidin-derived peptides for lung cancer diagnostics
- Patent Title (中): 用于肺癌诊断的皮肤素衍生肽
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Application No.: US12703102Application Date: 2010-02-09
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Publication No.: US09321818B2Publication Date: 2016-04-26
- Inventor: Chung-Hsuan Chen , Wei-Chao Chang , Michael Hsiao , Ming-Shyan Huang , Chih-Jen Yang
- Applicant: Chung-Hsuan Chen , Wei-Chao Chang , Michael Hsiao , Ming-Shyan Huang , Chih-Jen Yang
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Eckman Basu LLP
- Agent Shantanu Basu
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C07K14/47 ; A61K31/7088 ; A61K33/24 ; A61K38/04 ; A61K45/06 ; G01N33/574 ; G01N30/72 ; G01N33/68
Abstract:
Methods for diagnosis of non-small cell lung cancers by detection of endogenous peptides in exhaled breath condensate (EBC) are provided. Diagnostic peptides derived from dermcidin (DC) are provided. A specific dermcidin-derived peptide E-R11, having the sequence ENAGEDPGLAR (SEQ ID NO:2), is provided. E-R11 peptide levels in EBC, as measured by mass spectrometry (MS), are highly diagnostic of non-small cell lung cancers. A method for inhibiting growth of lung cancer cells by inhibiting DCD expression by RNA interference also is provided.
Public/Granted literature
- US20110195133A1 DERMCIDIN-DERIVED PEPTIDES FOR LUNG CANCER DIAGNOSTICS Public/Granted day:2011-08-11
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