Invention Grant
- Patent Title: Recombinant IgG4 monovalent antibodies
- Patent Title (中): 重组IgG4单价抗体
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Application No.: US12602419Application Date: 2008-05-30
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Publication No.: US09322035B2Publication Date: 2016-04-26
- Inventor: Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
- Applicant: Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
- Applicant Address: DK Copenhagen
- Assignee: GENMAB A/S
- Current Assignee: GENMAB A/S
- Current Assignee Address: DK Copenhagen
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Christopher L. Frank
- Priority: DK200700795 20070531
- International Application: PCT/DK2008/050127 WO 20080530
- International Announcement: WO2008/145140 WO 20081204
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12N15/85 ; C07K16/28
Abstract:
The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
Public/Granted literature
- US20100306867A1 TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS Public/Granted day:2010-12-02
Information query
