Invention Grant
- Patent Title: Activation and activators of SirT6
- Patent Title (中): SirT6的激活和激活者
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Application No.: US13516198Application Date: 2010-12-14
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Publication No.: US09322049B2Publication Date: 2016-04-26
- Inventor: Anthony Sauve , Ping Xu
- Applicant: Anthony Sauve , Ping Xu
- Applicant Address: US NY Ithaca
- Assignee: CORNELL UNIVERSITY
- Current Assignee: CORNELL UNIVERSITY
- Current Assignee Address: US NY Ithaca
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2010/060351 WO 20101214
- International Announcement: WO2011/081945 WO 20110707
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A61K31/185 ; C12Q1/48
Abstract:
The invention provides a method of increasing a deacetylated activity of SIRT6 by contacting SIRT6 with an agent that binds SIRT6 and reduces the Km of SIRT6 for a substrate, thereby increasing the deacetylase activity of SIRT6. The invention also provides compounds of the formulas (II) and (III).
Public/Granted literature
- US20130029930A1 ACTIVATION AND ACTIVATORS OF SIRT6 Public/Granted day:2013-01-31
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