In a computer system, a method of controls interrupts which correspond to input/output (I/O) processing. For each delivery of an I/O completion interrupt, the method provides a recordation of a delivery time; identifies I/O completions for which deliveries of corresponding I/O completion interrupts involve deliveries of inter-processor interrupts; and for each of the identified I/O completions, accesses the recordation of the most recent delivery time to determine whether a selected period of time has elapsed since a last delivery of an inter-processor interrupt. As a response to a determination that the selected period has elapsed, an inter-processor interrupt is delivers. As a response to a determination that less than the duration of the selected period has elapsed, the method refrains from delivering an inter-processor interrupt.