A signal path may operate in one of a plurality of gain modes such that for each gain mode, the product of a digital gain and an analog signal gain of the signal path associated with the particular gain mode are approximately equal to a fixed path gain. During each of one or more calibration phases, a calibration system may measure analog signals at a plurality of nodes of the first path portion, calculate an actual analog gain associated with the gain mode based on the analog signals measured at the plurality of nodes, calculate an error between the fixed path gain and a mathematical product of the actual analog gain associated with the gain mode and the digital gain associated with the gain mode, and modify at least one of the digital gain and the analog gain associated with the gain mode in conformity with the error.