To address the problem of inter-cell interference, the present invention proposes a method for inter-cell interference coordination and a device thereof. In one embodiment of the present invention, there is provided a method of coordinating radio resource in a base station of wireless communication network, comprising the steps of: S1 determining whether a UE is of interference risk; if the UE is of interference risk, then S2 determining key interference source base station(s) of the UE; S3, scheduling radio resource in collaboration with the key interference source base station(s), so that the key interference source base station(s) idle(s) the radio resource assigned to the UE by the base station. With the method and device provided in the present invention, effective avoidance of inter-cell interference may be achieved, and every cell may fully reuse resource to accomplish reuse gain, while UE backward compatibility may also be supported.