Invention Grant
US09353048B2 Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof
有权
化合物作为KCNQ钾通道激动剂，其制备方法及其应用
- Patent Title: Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof
- Patent Title (中): 化合物作为KCNQ钾通道激动剂，其制备方法及其应用
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Application No.: US14353842Application Date: 2012-10-23
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Publication No.: US09353048B2Publication Date: 2016-05-31
- Inventor: Fajun Nan , Min Li , Zhaobing Gao , Fei Chen , Yangming Zhang , Pingzheng Zhou , Haining Hu , Haiyan Xu , Sheng Liu
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai
- Agency: Kilpatrick Townsend & Stockton LLP
- Priority: CN201110328036 20111025
- International Application: PCT/CN2012/001423 WO 20121023
- International Announcement: WO2013/060097 WO 20130502
- Main IPC: C07C261/00
- IPC: C07C261/00 ; C07C271/28 ; C07D235/26 ; C07C233/43 ; C07C231/00 ; C07C233/44 ; C07C269/04
Abstract:
The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereofagonist, preparation methods therefor and a use thereof in the preparation of a medicine for the treatment of nervous system diseases. The compounds or pharmaceutical compositions thereof can be used as the KCNQ potassium channel agonist for treating nervous system diseases. Compared to retigabine, a compound in the prior art, the compound of the present invention have the same or better therapeutic effect, are easier for synthesis and storage, and less prone to oxidate deterioration.
Public/Granted literature
- US20140336252A1 NOVEL COMPOUND AS KCNQ POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF Public/Granted day:2014-11-13
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