Technologies for client-level web application runtime control and multi-factor security analysis by a computing device include receiving application code associated with a browser-based application from a web server. The computing device collects real-time data generated by at least one sensor of the computing device and performs a multi-factor security assessment of the browser-based application as a function of the collected real-time data and the application code. Further, the computing device establishes a client-level web application runtime security policy associated with the browser-based application in response to performing the multi-factor security assessment and enforces the client-level web application runtime security policy.