A method, a device and a system for signal transmission are disclosed in embodiments of the present invention. The method comprises: selecting a multiplexing mode of signals to be transmitted by a cell according to interference strength received by the cell and/or interference strength received by a neighboring cell; notifying a receiver of the multiplexing mode of the signals to be transmitted by the cell; and transmitting the signals to be transmitted by the cell according to the multiplexing mode of the signals to be transmitted by the cell. Through the signal transmission method, device and system provided herein, the multiplexing mode is selected adaptively according to the interference strength. Therefore, the inter-cell interference is reduced, the reliability of channel detection is improved, the system complexity is reduced, and the cost is saved.