发明授权
- 专利标题: Oral delivery of therapeutically effective LNA oligonucleotides
- 专利标题(中): 口服递送治疗有效的LNA寡核苷酸
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申请号: US13503189申请日: 2010-10-20
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公开(公告)号: US09364495B2公开(公告)日: 2016-06-14
- 发明人: Gregroy Hardee , Ellen Marie Straarup , Marie Wickstrom Lindholm , Henrik Orum , Henrik Hansen
- 申请人: Gregroy Hardee , Ellen Marie Straarup , Marie Wickstrom Lindholm , Henrik Orum , Henrik Hansen
- 申请人地址: DK Hoersholm
- 专利权人: Roche Innovation Center Copenhagen A/S
- 当前专利权人: Roche Innovation Center Copenhagen A/S
- 当前专利权人地址: DK Hoersholm
- 代理机构: Fish & Richardson P.C.
- 国际申请: PCT/EP2010/065766 WO 20101020
- 国际公布: WO2011/048125 WO 20110428
- 主分类号: C07H21/04
- IPC分类号: C07H21/04 ; C07H21/02 ; A61K48/00 ; C12N15/85 ; A61K31/712 ; C12N15/113
摘要:
The invention provides for LNA oligomers, for the treatment of a metabolic or liver disorder, wherein the LNA oligomer is administered orally in a unit dose of less than 50 mgs/kg, wherein the LNA oligomer is administered in the presence of a penetration (permeation) enhancer.