摘要:
A method of simulating fluid transport in a system for stimulating a well in a material formation of a resource reservoir, the system comprising a conduit element arranged in said well, the conduit element comprising a conduit wall including one or more openings for discharging a fluid into the material formation surrounding the conduit element; the method comprising establishing and numerically processing a transport model of fluid transport inside the conduit element. The transport model further includes a model of fluid transport in a predetermined space around said conduit element.
摘要:
The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.
摘要翻译:本公开内容涉及由选自下组的序列组成的LNA寡核苷酸:5' - (T x)X G x 例如,本发明的一个或多个实施方案,其中, x> T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T -3'和5' - (G x x)T x x T x >其中一个或多个第一个或更多个>> > 其中大写字母表示β-D-氧基,其中大写字母表示β-D-氧基, -LNA核苷酸类似物,小写字母表示2-脱氧核苷酸,下划线表示β-D-氧-LNA核苷酸类似物或2-脱氧核苷酸,下标“s”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接,下标 “x”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接或磷酸二酯连接,并且其中该序列是选择性的 最多延伸5个2-脱氧核苷酸单位。 LNA寡核苷酸可用于调节缺氧诱导因子-1a(HIF-1a)的表达,例如, 在治疗癌症疾病,抑制血管发生,诱导细胞凋亡,预防细胞增殖或治疗血管生成疾病,例如, 糖尿病性视网膜病变,黄斑变性(ARMD),牛皮癣,类风湿性关节炎等炎症性疾病。
摘要:
The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要:
Liquid resistant containers having double walled construction and an upwardly projecting container bottom are suitable for use, e.g., as a flower vase. Preferably, the containers are formed from a unitary carton blank having fold lines such that the container is prepared by folding the blank along fold lines to form the open-ended container, the cavity of which is lined with a liner or open bag to provide further resistance against leaks.
摘要:
In connection with the unreeling of a paper or foil web from a supply reel, e.g. in a flowpacking machine, it is well known to move the web through an adjustment station for maintaining a constant tension of the web in the outer length thereof. Normally, this is achieved by the use of a synchronously driven unreeling roller partially entwined by the web and a system for adjusting the degree of entwining based on a current detection of the web tension. With the invention this is simplified by driving the unreeling roller with a peripheral speed noticeably higher than the web speed, whereby it is possible with a suitable angle of entwining to achieve both a relatively low web tension and an automatically self-adjusting, constant web tension. By virtue of the associated, rather low dynamic friction between the roller and the web, it is even possible to effectively control or maintain the lateral positioning of the web merely by the use of simple abutments for co-operation with the side edges of the web.
摘要:
The invention provides for LNA oligomers, for the treatment of a metabolic or liver disorder, wherein the LNA oligomer is administered orally in a unit dose of less than 50 mgs/kg, wherein the LNA oligomer is administered in the presence of a penetration (permeation) enhancer.
摘要:
A medical balloon may be configured by at least partially inflating the medical balloon and forming at least one primary lobe in the balloon. The primary lobe extends from a central portion of the balloon. The primary lobe may be manipulated to form at least two secondary lobes therefrom. The balloon may then be deflated and the secondary lobes wrapped around the balloon.
摘要:
Process and apparatus for the preparation of synthesis gas by catalytic steam and/or CO2 reforming of a hydrocarbon feedstock comprising the following steps: (a) heating the reaction mixture of hydrocarbon and steam and/or CO2 in a heated steam reforming unit integrated with the flue gas containing waste heat section from the fired tubular reformer in which reforming of the reaction mixture takes place by contact with a solid reforming catalyst (b) feeding the partially steam reformed mixture to the fired tubular reformer and further reforming the mixture to the desired composition and temperature, wherein the heated steam reforming unit comprises a piping system containing reaction sections with solid reforming catalyst comprising catalyst pellets and/or catalysed structured elements, the piping system being part of the process gas piping system integrated with the flue gas-containing waste heat section.
摘要:
A method of controlling the speed of rotation of a turbine, the turbine comprising a rotor, the method comprising the steps of measuring or estimating power or torque related to the energy production of the turbine, processing the measured or estimated power or torque so as to obtain a corresponding rotational speed, comparing the obtained rotational speed to a first predefined threshold value and to a second predefined threshold value, the second predefined threshold value being larger than the first predefined threshold value, and controlling the speed of rotation of the rotor according to the obtained rotational speed, so as to obtain a predetermined energy production from the turbine, and in such a way that in case the obtained rotational speed does not exceed the first predefined threshold value, the predetermined energy production from the turbine is optimal, in case the obtained rotational speed exceeds the first predefined threshold value, but does not exceed the second predefined threshold value, the predetermined energy production from the turbine is optimal, in case the obtained rotational speed exceeds the second predefined threshold value, the speed of rotation of the rotor of the turbine is reduced in a predefined manner to a value corresponding to the first predefined threshold value.
摘要:
A system for optimising the production performance of a milk producing animal herd is provided. The system comprises a milk sampling apparatus, an analytical apparatus comprising separate equipment for analyzing compounds or parameters that in the presence of compounds indicative of the physiological or nutritional condition of the herd member, generates detectable signals, and apparatus directing a part of the milk sample (directing apparatus) to each separate equipment, which is controlled by data for the physiological and nutritional state of a herd member, so that the directing apparatus is only activated at pre-selected points in time or at pre-selected time intervals in the production and/or lactation cycles. Specific compounds are compounds indicative of mastitis, including beta-N-acetylhexosaminidase (NAGase) E.C. 3.2.1.52 and lactate dehydrogenase (LDH), protein balance, including milk urea nitrogen (MUN) and total protein, ketosis, including acetolactate, beta-hydroxybutyrate, acetone and lipids, fat and state in reproduction cycle, including a steroid or peptide hormone, e.g., progesterone. Furthermore, the system comprises equipment for signal detection to record and process the signals, equipment to store data and equipment to produce data output. Methods for optimizing the production performance of a milk producing animal herd and an apparatus therefor.