发明授权
- 专利标题: Soluble guanylate cyclase activators
- 专利标题(中): 可溶性鸟苷酸环化酶活化剂
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申请号: US13699046申请日: 2011-05-24
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公开(公告)号: US09365574B2公开(公告)日: 2016-06-14
- 发明人: Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
- 申请人: Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Eric A. Meade; Anna L. Cocuzzo
- 国际申请: PCT/US2011/037718 WO 20110524
- 国际公布: WO2011/149921 WO 20111201
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D519/00 ; A61K31/519 ; A61P29/00 ; A61P9/12 ; A61P3/10 ; A61P9/10 ; A61P11/06 ; A61P15/10 ; A61P9/04 ; A61P13/12 ; A61P1/16
摘要:
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.
公开/授权文献
- US20130072492A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS 公开/授权日:2013-03-21
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