公开(公告)号：US09365574B2

公开(公告)日：2016-06-14

申请号：US13699046

申请日：2011-05-24

Applicant: Subharekha Raghavan ,  John E. Stelmach ,  Cameron J. Smith ,  Hong Li ,  Alan Whitehead ,  Sherman T. Waddell ,  Yi-Heng Chen ,  Shouwu Miao ,  Olga A. Ornoski ,  Joie Garfunkle ,  Xibin Liao ,  Jiang Chang ,  Xiaoqing Han ,  Jian Guo ,  Jonathan A. Groeper ,  Linda L. Brockunier ,  Keith Rosauer ,  Emma R. Parmee

Inventor： Subharekha Raghavan ,  John E. Stelmach ,  Cameron J. Smith ,  Hong Li ,  Alan Whitehead ,  Sherman T. Waddell ,  Yi-Heng Chen ,  Shouwu Miao ,  Olga A. Ornoski ,  Joie Garfunkle ,  Xibin Liao ,  Jiang Chang ,  Xiaoqing Han ,  Jian Guo ,  Jonathan A. Groeper ,  Linda L. Brockunier ,  Keith Rosauer ,  Emma R. Parmee

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61P29/00 ,  A61P9/12 ,  A61P3/10 ,  A61P9/10 ,  A61P11/06 ,  A61P15/10 ,  A61P9/04 ,  A61P13/12 ,  A61P1/16

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D519/00

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract translation: 式（I）的化合物或其药学上可接受的盐能够调节身体的环鸟苷酸（“cGMP”）的产生，并且通常适用于治疗和预防与受干扰的cGMP平衡相关的疾病 。 本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式（III）化合物的药物制剂 I）或其药学上可接受的盐。

公开(公告)号：US20130072492A1

公开(公告)日：2013-03-21

申请号：US13699046

申请日：2011-05-24

Applicant: Subharekha Raghavan ,  John E. Stelmach ,  Cameron J. Smith ,  Hong Li ,  Alan Whitehead ,  Sherman T. Waddell ,  Yi-Heng Chen ,  Shouwu Miao ,  Olga A. Ornoski ,  Joie Garfunkle ,  Xibin Liao ,  Jiang Chang ,  Xiaoqing Han ,  Jian Guo ,  Jonathan A. Groeper ,  Linda L. Brockunier ,  Keith Rosauer ,  Emma R. Parmee

Inventor： Subharekha Raghavan ,  John E. Stelmach ,  Cameron J. Smith ,  Hong Li ,  Alan Whitehead ,  Sherman T. Waddell ,  Yi-Heng Chen ,  Shouwu Miao ,  Olga A. Ornoski ,  Joie Garfunkle ,  Xibin Liao ,  Jiang Chang ,  Xiaoqing Han ,  Jian Guo ,  Jonathan A. Groeper ,  Linda L. Brockunier ,  Keith Rosauer ,  Emma R. Parmee

IPC: C07D487/04 ,  C07D495/04 ,  A61K31/5025 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P9/04 ,  A61P7/02 ,  A61P15/00 ,  A61P11/06 ,  A61P13/12 ,  A61P3/10 ,  A61P1/16 ,  A61P9/08 ,  A61P3/00 ,  A61P3/06 ,  A61P7/10 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D519/00

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract translation: 式（I）的化合物或其药学上可接受的盐能够调节人体的环鸟苷酸（cGMP）的产生，并且通常适用于治疗和预防与扰动的cGMP平衡有关的疾病。 本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式（III）化合物的药物制剂 I）或其药学上可接受的盐。