Invention Grant
- Patent Title: Soluble guanylate cyclase activators
- Patent Title (中): 可溶性鸟苷酸环化酶活化剂
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Application No.: US13699046Application Date: 2011-05-24
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Publication No.: US09365574B2Publication Date: 2016-06-14
- Inventor: Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
- Applicant: Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Eric A. Meade; Anna L. Cocuzzo
- International Application: PCT/US2011/037718 WO 20110524
- International Announcement: WO2011/149921 WO 20111201
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; A61K31/519 ; A61P29/00 ; A61P9/12 ; A61P3/10 ; A61P9/10 ; A61P11/06 ; A61P15/10 ; A61P9/04 ; A61P13/12 ; A61P1/16

Abstract:
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20130072492A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS Public/Granted day:2013-03-21
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