A pneumatic tire comprises a tread portion with a left-right asymmetry tread pattern including inboard and outboard tread edges, a pair of inboard and outboard center main grooves to form a center portion therebetween, a pair of inboard and outboard shoulder main grooves to form a pair of middle portions and a pair of shoulder portions, inboard lateral main grooves extending from the inboard tread edge beyond the tire equator without reaching the outboard center main groove, inboard shoulder lateral grooves between adjacent inboard lateral main grooves, outboard shoulder lateral grooves extending from the axially outside of the outboard tread edge without reaching the outboard shoulder main groove, inboard middle lateral grooves between adjacent inboard lateral main grooves and extending from the inboard shoulder main groove without reaching the inboard center main groove, outboard middle lateral grooves and outboard middle sub lateral grooves.