Invention Grant
- Patent Title: Variant activin IIB receptor
-
Application No.: US14204460Application Date: 2014-03-11
-
Publication No.: US09382309B2Publication Date: 2016-07-05
- Inventor: Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Fenwick & West LLP
- Main IPC: C07K14/71
- IPC: C07K14/71

Abstract:
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Public/Granted literature
- US09447165B2 Variant activin IIB receptor Public/Granted day:2016-09-20
Information query