中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

29 records (took 0.027 seconds)

    Isolated nucleic acid molecule encoding a fusion protein comprising an activin receptor
    1.
    发明授权
    Isolated nucleic acid molecule encoding a fusion protein comprising an activin receptor 有权
    分离的编码包含激活素受体的融合蛋白的核酸分子

    公开(公告)号：US09284364B2

    公开(公告)日：2016-03-15

    申请号：US14085056

    申请日：2013-11-20

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C12P21/06 ,  C12N5/02 ,  C12N15/00 ,  C07K14/71

    CPC classification number: C07K14/71 ,  C07K2319/30

    Abstract: The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

    Abstract translation: 本发明提供能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的新型激活素IIB5受体多肽。 本发明还提供能够产生受体多肽的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦，代谢和其它疾病的组合物和方法。

    Anti-activin A antibodies and uses thereof
    5.
    发明授权
    Anti-activin A antibodies and uses thereof 有权

    公开(公告)号：US10100109B2

    公开(公告)日：2018-10-16

    申请号：US15346617

    申请日：2016-11-08

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K16/00 ,  C07K16/42 ,  C07K16/22 ,  A61K39/00

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    Anti-activin A antibodies and uses thereof
    6.
    发明授权
    Anti-activin A antibodies and uses thereof 有权

    公开(公告)号：US11542325B2

    公开(公告)日：2023-01-03

    申请号：US16128831

    申请日：2018-09-12

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: A61K39/395 ,  A61K39/00 ,  C07K16/22

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    7.
    发明申请
    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：US20180371073A1

    公开(公告)日：2018-12-27

    申请号：US16128831

    申请日：2018-09-12

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K16/22 ,  A61K39/00

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    Variant Activin Receptor
    9.
    发明申请
    Variant Activin Receptor 有权
    变异激活素受体

    公开(公告)号：US20160264644A1

    公开(公告)日：2016-09-15

    申请号：US15171944

    申请日：2016-06-02

    Applicant: Amgen Inc.

    Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Hui-Quan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

    Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

    Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。

Patent Agency Ranking